CD45 (PTPRC) Mouse Monoclonal Antibody [Clone ID: OTI3E3]
Specifications
Product Data | |
Clone Name | OTI3E3 |
Applications | FC, IF, WB |
Recommended Dilution | WB 1:400~8000, IF 1:100, FLOW 1:50 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human PTPRC(NP_002829) produced in HEK293T cell. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 147.1 kDa |
Gene Name | protein tyrosine phosphatase receptor type C |
Database Link | |
Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] |
Synonyms | B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane |
Protein Pathways | Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF506545 | Carrier-free (BSA/glycerol-free) PTPRC mouse monoclonal antibody, clone OTI3E3 (formerly 3E3) |
USD 600.00 |
|
TA506545 | PTPRC mouse monoclonal antibody, clone OTI3E3 (formerly 3E3) |
USD 447.00 |
|
TA506545AM | PTPRC mouse monoclonal antibody, clone OTI3E3 (formerly 3E3), Biotinylated |
USD 509.00 |
|
TA506545BM | PTPRC mouse monoclonal antibody, clone OTI3E3 (formerly 3E3), HRP conjugated |
USD 509.00 |
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