JNK1 (MAPK8) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI4E3]
CAT#: TA500081BM
JNK1 (MAPK8) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3), HRP conjugated
Conjugation: Unconjugated Biotin
USD 867.00
USD 436.00
Specifications
Product Data | |
Clone Name | OTI4E3 |
Applications | IF, IHC, WB |
Recommended Dilution | WB 1:500, IHC 1:50, IF 1:100 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 (NP_002741) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
Concentration | 0.5 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | HRP |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 44.0 kDa |
Gene Name | mitogen-activated protein kinase 8 |
Database Link | |
Background | JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK1 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of JNK1 by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. JNK1 is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of JNK1 gene suggested that it play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Synonyms | JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase |
Protein Pathways | Adipocytokine signaling pathway, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Fc epsilon RI signaling pathway, Focal adhesion, GnRH signaling pathway, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Wnt signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
CF500081 | Carrier-free (BSA/glycerol-free) JNK1 mouse monoclonal antibody, clone OTI4E3 (formerly 4E3) |
USD 600.00 |
|
TA500081 | JNK1 (MAPK8) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3) |
USD 447.00 |
|
TA500081AM | JNK1 (MAPK8) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3), Biotinylated |
USD 509.00 |
|
TA500081S | JNK1 (MAPK8) mouse monoclonal antibody, clone OTI4E3 (formerly 4E3) |
USD 200.00 |
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