c Fos (FOS) Mouse Monoclonal Antibody [Clone ID: 2H2]

CAT#: TA389000

Anti-c-FOS Antibody

Specifications

Product Data

• Clone Name: 2H2
• Applications: ICC, IHC, WB
• Recommended Dilution: WB: 1:2000
  ICC: 1:1000
• Reactivities: Bovine, Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant full length human c-FOS expressed in and purified from E. Coli.
• Specificity: Specific for endogenous levels of the ~50 kDa c-FOS protein.
• Formulation: PBS + 50% glycerol and 5 mM NaN3
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Stability: After date of receipt, stable for at least 1 year at -20°C.
• Predicted Protein Size: 50
• Gene Name: Fos proto-oncogene, AP-1 transcription factor subunit
• Database Link:
  Entrez Gene 2353 Human
  UniProt ID P01100
• Background: c-FOS is a member of the FOS transcription factor family which forms dimers with c-JUN to produce the Activator Protein 1 (AP-1) complex which plays a key role in critical cellular processes such as cell proliferation, differentiation and apoptosis (Chiu et al., 1988). c-FOS expression has been demonstrated to be a useful marker of neuronal activation as it is rapidly induced following various stimuli (Hoffman et al., 1993). Additionally, c-FOS has been shown to be overexpressed in a variety of malignant tumor types (Milde-Langosch 2005).
• Synonyms: AP-1; C-FOS; G0S7
• Note: Protein G purified culture supernatant.