Il6ra Rabbit Monoclonal Antibody [Clone ID: D7715A7]
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Specifications
Product Data | |
Clone Name | D7715A7 |
Applications | Bl, FC |
Reactivities | Mouse |
Host | Rabbit |
Isotype | IgG, kappa |
Clonality | Monoclonal |
Immunogen | This antibody was raised by immunising Lewis rats with OKT4 cells. |
Specificity | This antibody is specific for murine IL-6R. This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001). |
Formulation | PBS with 0.02% Proclin 300. |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage | Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles. |
Stability | 3 years from dispatch. |
Gene Name | interleukin 6 receptor, alpha |
Database Link | |
Synonyms | CD126; IL-6R; Il6r |
Note | This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques. |
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