VDAC1 Rabbit Monoclonal Antibody [Clone ID: R05-7F2]

CAT#: TA385546

VDAC1 Rabbit monoclonal Antibody

Product Images

Western blot analysis of VDAC1 in rat kidney, mouse kidney lysates using VDAC1 antibody.

• 

  Western blot analysis of VDAC1 in 293 lysates using VDAC1 antibody.

• 

  Western blot analysis of VDAC1 in Jurkat, rat Brain, C6 lysates using VDAC1 antibody

• 

  Immunohistochemistry analysis of paraffin-embedded Human colon cancer using VDAC1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R05-7F2
• Applications: IHC, WB
• Recommended Dilution: WB: 1/2000
  IHC: 1/20-1/500
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide of human VDAC1
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 31 kDa; Observed MW: 31 kDa
• Gene Name: voltage dependent anion channel 1
• Database Link:
  Entrez Gene 7416 Human
  UniProt ID P21796
• Background: Swiss-Prot Acc.P21796.Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).
• Synonyms: hVDAC1; MGC111064; OTTHUMP00000159381; OTTHUMP00000165946; PORIN; PORIN-31-HL; VDAC; VDAC-1