TRIM56 Rabbit Monoclonal Antibody [Clone ID: R02-8A3]
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USD 200.00
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Specifications
Product Data | |
Clone Name | R02-8A3 |
Applications | IF, WB |
Recommended Dilution | WB: 1/2000-1/10000 ICC/IF: 1/50-1/100 |
Reactivities | Human |
Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human TRIM56 |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Stability | 1 year |
Predicted Protein Size | Calculated MW: 82 kDa; Observed MW: 82 kDa |
Gene Name | tripartite motif containing 56 |
Database Link | |
Background | Swiss-Prot Acc.Q9BRZ2.E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160). |
Synonyms | DKFZp667O116; FLJ35608; RNF109 |
Reference Data |
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