DNAJB6 Rabbit Monoclonal Antibody [Clone ID: R01-8K2]

CAT#: TA384111

DNAJB6 Rabbit monoclonal Antibody

Product Images

Western blot detection of DNAJB6 in K562,Rat Brain,C6,3T3,Hela cell lysates using DNAJB6 Rabbit mAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:36kDa.

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  Immunohistochemistry analysis of paraffin-embedded mouse colon using DNAJB6 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Specifications

Product Data

• Clone Name: R01-8K2
• Applications: IHC, WB
• Recommended Dilution: WB: 1/1000
  IHC: 1/20
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human DNAJB6
• Formulation: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Predicted Protein Size: Calculated MW: 36 kDa; Observed MW: 36 kDa
• Gene Name: DnaJ heat shock protein family (Hsp40) member B6
• Database Link:
  Entrez Gene 10049 Human
  UniProt ID O75190
• Background: Swiss-Prot Acc.O75190.Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
• Synonyms: DJ4; DKFZp566D0824; DnaJ; FLJ42837; HHDJ1; HSJ-2; HSJ2; MGC1152; MGC117297; MRJ; MSJ-1; MSJ1