GLUD1 Rabbit Polyclonal Antibody
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Other products for "GLUD1"
Specifications
Product Data | |
Applications | ICC/IF, IHC, IP, WB |
Recommended Dilution | WB,1:500 - 1:2000 IHC,1:100 - 1:200 IF,1:50 - 1:200 IP,1:50 - 1:200 |
Reactivities | Human, Mouse, Rat |
Modifications | Unmodified |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 54-240 of human GLUD1 (NP_005262.1). |
Formulation | PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 42kDa/46kDa/61kDa |
Gene Name | glutamate dehydrogenase 1 |
Database Link | |
Background | This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. |
Synonyms | GDH; GDH1; GLUD; MGC132003 |
Reference Data |
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