CACNA1C Rabbit Polyclonal Antibody

CAT#: TA371277

CACNA1C rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA371277 (CACNA1C Antibody) at dilution 1/20 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using TA371277 (CACNA1C Antibody) at dilution 1/20, treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-100
  Positive control: Human thyroid cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CACNA1C
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: calcium voltage-gated channel subunit alpha1 C
• Database Link:
  Entrez Gene 775 Human
  UniProt ID Q13936
• Background: This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.
• Synonyms: CACH2; CACN2; CACNL1A1; CaV1.2; CCHL1A1; MGC120730; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196739; OTTHUMP00000196744; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196751; TS