DENND1A Rabbit Polyclonal Antibody

CAT#: TA365751

DENND1A rabbit polyclonal antibody

Product Images

Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA365751 (DENND1A Antibody) at dilution 1/90 (Original magnification: ×200)

• 

  Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using TA365751 (DENND1A Antibody) at dilution 1/90, treated with fusion protein. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 50-200
  Positive control: Human gastric cancer
  Predicted cell location: Cell membrane
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human DENND1A
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Gene Name: DENN domain containing 1A
• Database Link:
  Entrez Gene 57706 Human
  UniProt ID Q8TEH3
• Background: Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).
• Synonyms: Connecdenn; FAM31A; FLJ21129; FLJ38464; KIAA1608; RP11-230L22.3