Topoisomerase III alpha (TOP3A) Rabbit Polyclonal Antibody

CAT#: TA362263

TOP3A Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: TOP3A Sample Tissue: Human PC-3 Whole Cell lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of Human TOP3A
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 101 kDa
• Gene Name: topoisomerase (DNA) III alpha
• Database Link:
  NP_004609.1
  Entrez Gene 7156 Human
  UniProt ID Q13472-3
• Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Synonyms: TOP3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Homologous recombination