CYP27B1 Rabbit Polyclonal Antibody

CAT#: TA360988

CYP27B1 Antibody - C-terminal region

Product Images

Host: Rabbit Target Name: CYP27B1 Sample Tissue: Human Leiomyosarcoma Tumor lysates Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human CYP27B1
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 56 kDa
• Gene Name: cytochrome P450 family 27 subfamily B member 1
• Database Link:
  NP_000776.1
  Entrez Gene 1594 Human
  UniProt ID O15528
• Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.
• Synonyms: 1alpha(OH)ase; CP2B; CYP1; CYP1alpha; CYP27B; P450c1; P450C1-alpha; P450VD1-alpha; PDDR; VDD1; VDDR; VDDRI; VDR

Reference Data

• Protein Families: Druggable Genome, P450
• Protein Pathways: Metabolic pathways, Steroid biosynthesis