HMGCR Rabbit Polyclonal Antibody

CAT#: TA360539

HMGCR Antibody - middle region

Product Images

Host: Rabbit Target Name: HMGCR Sample Tissue: Human PANC1Â Whole Cell lysates Antibody Dilution: 1ug/ml

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  Host: Mouse Target Name: HMGCR Sample Tissue: Mouse Pancreas Antibody Dilution: 1ug/ml

Specifications

Product Data

• Applications: WB
• Reactivities: Human, Mouse
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human HMGCR
• Specificity: Expected reactivity: Human
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: 98 kDa
• Gene Name: 3-hydroxy-3-methylglutaryl-CoA reductase
• Database Link:
  NP_000850.1
  Entrez Gene 15357 MouseEntrez Gene 3156 Human
  UniProt ID P04035
• Background: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: LDLCQ3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Metabolic pathways, Terpenoid backbone biosynthesis