H.PYLORI Mouse Monoclonal Antibody [Clone ID: ULC3R]

CAT#: TA355304

H.PYLORI Mouse Monoclonal Antibody

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Specifications

Product Data

• Clone Name: ULC3R
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Helicobacter pylori
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 151 amino acids of the HopE molecule
• Specificity: Helicobacter pylori
• Formulation: Liquid tissue culture supernatant containing 15 mM sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Background: Helicobacter pylori is a motile, helix-shaped Gram-negative, microaerophilic, bacterial pathogen which is capable of converting from a spiral form to a coccoid form to favor its survival. Almost 50% of the world's population, approaching 100% in some countries, are infected. There are numerous strains of Helicobacter pylori which can be grouped into two broad families, type I and type II, based on their expression of the hopQ allele. Type I and type II strains are reported to express VacA (vacuolating toxin) responsible for vacuolation of gastric epithelial cells and induction of apoptosis. Type I strains are reported to express CagA protein which is associated with deregulation of intercellular signaling pathways and initiation of pathogenesis (virulent strains) and are closely related to gastric diseases such as peptic ulceration, gastric ulceration, chronic gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma and intestine type gastric adenocarcinomas. Type II strains are reported not to express CagA proteins. HopE is a 31 kD porin protein which is part of a family of 32 outer membrane proteins present in Helicobacter pylori bacteria. HopE is highly conserved in Helicobacter pylori strains, but not among other strains of the Helicobacter genus.