CD10 (MME) Mouse Monoclonal Antibody [Clone ID: 56C6]

CAT#: TA355243

CD10 Mouse Monoclonal Antibody

Product Images

Human tonsil: immunohistochemical staining for CD10. Note membrane staining of germinal centre B cells. CD10: clone 56C6

Specifications

Product Data

• Clone Name: 56C6
• Applications: IHC
• Recommended Dilution: 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant fusion protein corresponding to the external domain of the human CD10 glycoprotein
• Specificity: Human CD10 molecule, also known as common acute lymphocytic leukemia antigen (CALLA)
• Formulation: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Gene Name: membrane metallo-endopeptidase
• Database Link:
  Entrez Gene 4311 Human
  UniProt ID P08473
• Background: CD10 antigen, also called neprilysin, is a 100 kD cell surface metalloendopeptidase which inactivates a variety of biologically active peptides. It was initially identified as the common acute lymphoblastic leukemia antigen (CALLA) and was thought to be tumor-specific. Subsequent studies, however, have shown that CD10 antigen is expressed on the surface of a wide variety of normal and neoplastic cells. In other lymphoid malignancies, CD10 antigen is reported to be expressed on cells of lymphoblastic, Burkitt's and follicular lymphomas. CD10 antigen has been identified on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. It is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. (G. McIntosh et al. American Journal of Pathology. 154(1): 77-82 (1999)).
• Synonyms: atriopeptidase; CALLA; CD10; DKFZp686O16152; Enkephalinase; EPN; MGC126681; MGC126707; NEP; neprilysin