Lymphocyte Activation Gene 3 (LAG3) Mouse Monoclonal Antibody [Clone ID: 1G4]
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Specifications
Product Data | |
Clone Name | 1G4 |
Applications | ELISA, FC, IF, IHC, WB |
Recommended Dilution | ELISA start at 0.25 ug/mL. WB start at 0.25 ug/mL. ICC start at 1 ug/mL. IF start at 10 ug/mL. IHC start at 5 ug/mL. FC start at 1 ug/mL. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | LAG-3 antibody was raised against the extracellular domain of human LAG-3 |
Formulation | LAG-3 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | LAG-3 Antibody is supplied as protein A purified IgG1. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | Predicted: 55 kDa; Observed: 60, 70, 80 kDa |
Gene Name | lymphocyte activating 3 |
Database Link | |
Background | The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity, negatively regulating T-cell function and homeostasis.It is expressed in B, T, and NK cells, monocytes, and dendritic cells, and acts to regulate T cell expansion. LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy. |
Synonyms | CD223; FDC; LAG-3 |
Reference Data |
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