PIM2 Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human pim-2 oncogene (PIM2), 20 µg
USD 867.00
Other products for "PIM2"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Fusion protein of human PIM2 |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | Pim-2 proto-oncogene, serine/threonine kinase |
Database Link | |
Background | This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. |
Synonyms | Pim-2h |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Acute myeloid leukemia |
Documents
Product Manuals |
FAQs |
SDS |
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in shipping.