Parkin (PARK2) Rabbit Polyclonal Antibody
Frequently bought together (2)
Other products for "Parkin"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 1:500-1:3000 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | The immunogen for anti-Parkin Antibody: A synthesized peptide derived from human Parkin |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt |
Concentration | lot specific |
Purification | Affinity-chromatography |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 52 kDa |
Gene Name | parkin RBR E3 ubiquitin protein ligase |
Database Link | |
Background | PARK2 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. |
Synonyms | AR-JP; LPRS2; PDJ; PRKN |
Note | Parkin antibody detects endogenous levels of total Parkin |
Reference Data | |
Protein Pathways | Parkinson's disease, Ubiquitin mediated proteolysis |
Documents
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