TCHP Rabbit Polyclonal Antibody

CAT#: TA342972

Rabbit Polyclonal Anti-TCHP Antibody

Product Images

WB Suggested Anti-TCHP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human Liver

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TCHP antibody: synthetic peptide directed towards the C terminal of human TCHP. Synthetic peptide located within the following region: IQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLKSARKQE
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 61 kDa
• Gene Name: trichoplein keratin filament binding
• Database Link:
  NP_115676
  Entrez Gene 84260 Human
  UniProt ID Q9BT92
• Background: TCHP is a tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. It inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. It may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. And it also may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
• Synonyms: TpMs
• Note: Immunogen Sequence Homology: Pig: 100%; Rat: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Bovine: 100%; Guinea pig: 100%; Yeast: 91%; Dog: 86%; Rabbit: 86%