TWEAK (TNFSF12) Rabbit Polyclonal Antibody

CAT#: TA341640

Rabbit Polyclonal Anti-TNFSF12 Antibody

Product Images

WB Suggested Anti-TNFSF12 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: 721_B cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-TNFSF12 antibody: synthetic peptide directed towards the N terminal of human TNFSF12. Synthetic peptide located within the following region: LGLLLAVVSLGSRASLSAQEPAQEELVAEEDQDPSELNPQTEESQDPAPF
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 17 kDa
• Gene Name: tumor necrosis factor superfamily member 12
• Database Link:
  NP_003800
  Entrez Gene 8742 Human
  UniProt ID O43508
• Background: The protein encoded byThis gene is a cytokine that belongs toThe tumor necrosis factor (TNF) ligand family.This protein is a ligand forThe FN14/TWEAKR receptor.This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner.This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skipThe last exon ofThis gene and continue intoThe second exon ofThe neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
• Synonyms: APO3L; DR3LG; TWEAK
• Note: Immunogen Sequence Homology: Human: 100%; Horse: 93%; Rat: 86%; Mouse: 83%; Rabbit: 83%; Zebrafish: 82%; Dog: 79%

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction