TRAF5 Mouse Monoclonal Antibody [Clone ID: 55A219]

CAT#: TA336671

Mouse Monoclonal TRAF-5 Antibody (55A219)

Product Images

Western Blot: TRAF-5 Antibody (55A219) TA336671 - Analysis of TRAF-5 using this antibody at 2 ug/ml dilution against 10 ug of HeLa cell lysate.

Specifications

Product Data

• Clone Name: 55A219
• Applications: WB
• Recommended Dilution: Western Blot: 2 ug/ml
• Reactivities: Human
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Anti-TRAF5 monoclonal antibody was raised against a fusion protein corresponding to amino acids 77 to 186 of human TRAF5.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TNF receptor associated factor 5
• Database Link:
  NP_665702
  Entrez Gene 7188 Human
  UniProt ID O00463
• Background: Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation.
• Synonyms: MGC:39780; RNF84
• Note: This antibody can be used in Western Blot where a 66 kDa band is seen (predicted molecular weight 66.8 kDa).

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Pathways in cancer, Small cell lung cancer