Aqp7 Rabbit Polyclonal Antibody
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Other products for "Aqp7"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 1:200-1:2000; IHC: 1:100-1:3000 |
Reactivities | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide corresponding to amino acid? residues 7-24 of rat AQP-7. Intracellular, N-terminus. |
Formulation | Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3. |
Reconstitution Method | Add 50 ul double distilled water (DDW) to the lyophilized powder. |
Purification | Affinity purified on immobilized antigen. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | aquaporin 7 |
Database Link | |
Background | Aquaporin 7 (AQP-7) belongs to a family of membrane proteins that allow passage of water and certain other solutes through biological membranes. The family is composed of 13 members (AQP-0 to AQP-12). Little is known about the function of the two newest members, AQP-11 and AQP-12. The aquaporins can be divided into two functional groups based on their permeability characteristics: the aquaporins that are only permeated by water and the aquaglyceroporins that are permeated by water and other small solutes such as glycerol. This last group includes AQP-7, AQP-3, AQP-9 and AQP-10. The proteins present a conserved structure of six transmembrane domains with intracellular N- and C-termini. The functional channel is a tetramer but each subunit has a separate pore and therefore the functional channel unit, contains four pores. AQP-7 is expressed in ovary, testis, kidney and adipose tissue. The function of AQP-7 in adipose tissue attracted much interest as mice deficient in AQP-7 developed adult-onset obesity and type 2 diabetes. AQP-7 modulates adipocyte glycerol permeability thereby controlling triglyceride accumulation and fat cell size |
Synonyms | AQP-7; AQP7L; AQP9; AQPap; Aquaporin-7-like; MGC149555; MGC149556 |
Reference Data |
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