Thrombomodulin (THBD) Mouse Monoclonal Antibody [Clone ID: 1009]

CAT#: TA327745

Mouse Monoclonal Thrombomodulin Antibody

Product Images

Immunohistochemistry staining of Paraffin Bladder, mesothelioma tissue by Thrombomodulin antibody (dilution: 1:25 - 1:100; visualization of staining: Membranous, cytoplasmic)

Specifications

Product Data

• Clone Name: 1009
• Applications: IHC
• Recommended Dilution: IHC: 1:25 - 1:100
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Formulation: This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: thrombomodulin
• Database Link:
  NP_000352
  Entrez Gene 7056 Human
  UniProt ID P07204
• Synonyms: AHUS6; BDCA3; CD141; THPH12; THRM; TM
• Note: Thrombomodulin (TM) is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD) with natural anticoagulant properties. It is normally expressed by a restricted number of cells such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express TM. Several immunohistochemical endothelial markers are currently available and anti-thrombomodulin serves as another such marker, staining blood and lymphatic channels consistently. Anti-TM has demonstrated positivity in 100% of benign vascular tumors (pyogenic granuloma and hemangioma) and 94% of malignant vascular tumors (Kaposi’s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-TM serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of anti-TM as an immunohistochemical marker for mesothelial cells and malignant mesotheliomas. Anti-TM is immunoexpressed in a variety of other tumors including squamous cell carcinomas of the lung, synovial sarcoma, transitional cell carcinoma, renal cell carcinomas, and thymomas.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Complement and coagulation cascades