Dynamitin (DCTN2) Rabbit Polyclonal Antibody

CAT#: TA327334

Rabbit anti-DCTN2 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using DCTN2 antibody.

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  Immunofluorescence analysis of U2OS cell using DCTN2 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50- 1:200
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human DCTN2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dynactin subunit 2
• Database Link:
  NP_006391
  Entrez Gene 299850 RatEntrez Gene 10540 Human
  UniProt ID Q13561
• Background: Dynamitin is a 50 kDa protein containing a calmodulin binding domain, a putative ATPase domain and MacMARCKS-binding domain. This protein is a part of the dynactin complex believed to link the dynactin complex to membrane compartments. Its functions are tightly associated with dynein motor protein, thus extend to vesicle trafficking and membrane integrity. Dynamitin was named so because its overexpression causes dynactin complex which contains 10 subunits, to disassemble. Its N terminal 58 amino acid is for MacMARCKS binding and residues 59-83 is responsible for calmodulin binding. This antibody is against the full length p50 dynamitin.
• Synonyms: DCTN50; DYNAMITIN; HEL-S-77; RBP50

Reference Data

• Protein Pathways: Huntington's disease