HNF 4 alpha (HNF4A) Rabbit Polyclonal Antibody

CAT#: TA327262

Rabbit anti-HNF4A Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using HNF4A antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide of human HNF4A
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: hepatocyte nuclear factor 4 alpha
• Database Link:
  NP_000448
  Entrez Gene 3172 Human
  UniProt ID P41235
• Background: Hepatocyte nuclear factor 4a (HNF4a) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver.HNF4a, in association with PGC-1a, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers . Conditional knockout of the HNF4a gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels . Mutations in HNF4a have been linked to maturity-onset diabetes of the young (MODY) .
• Synonyms: FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young