PBP (PEBP1) Rabbit Polyclonal Antibody
Frequently bought together (3)
Transient overexpression lysate of phosphatidylethanolamine binding protein 1 (PEBP1)
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Recombinant protein of human phosphatidylethanolamine binding protein 1 (PEBP1), 20 µg
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Other products for "PBP"
Specifications
Product Data | |
Applications | ICC/IF, IP, WB |
Recommended Dilution | WB 1:500 - 1:2000;IF 1:50 - 1:200;IP 1:20 - 1:50 |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human PEBP1 |
Formulation | Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Concentration | lot specific |
Purification | Affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 21 kDa |
Gene Name | phosphatidylethanolamine binding protein 1 |
Database Link | |
Background | Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding protein (PEBP) family that associates with Raf-1 and the MEK and MAP kinases. RKIP has been shown to complex with Raf-1, MEK, and ERK. Although MEK and ERK can simultaneously bind RKIP, the association between Raf-1 and RKIP and that of RKIP and MEK are mutually exclusive. Thus, RKIP competitively disrupts the Raf-1-MEK complex and effectively terminates signal transmission from Raf-1 to MAP kinases. The inhibitory effect of RKIP on MAP kinase signaling is eliminated by PKC phosphorylation of RKIP at Ser153. PKC phosphorylation on Ser153 also promotes the association of RKIP with GRK2, which prevents GRK2-dependent internalization of GPCR. RKIP also interacts with modules of the NF-?B pathway, including NF-?B-inducing kinase (NIK), TAK1, IKKa and IKKβ. These interactions antagonize cytokine-induced activation of the NF-?B pathway. Restoration of RKIP expression is associated with the inhibition of prostate cancer metastasis, implying that RKIP may be a potential clinical target as a suppressor of tumor metastasis through inhibition of vascular invasion. |
Synonyms | HCNP; HCNPpp; HEL-210; HEL-S-34; HEL-S-96; PBP; PEBP; PEBP-1; RKIP |
Reference Data |
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