SCUBE3 Rabbit Polyclonal Antibody

CAT#: TA326605

Rabbit Polyclonal SCUBE3 Antibody

Product Images

Immunohistochemistry of SCUBE3 in blood vessel tissue with SCUBE3 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3.
• Formulation: SCUBE3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SCUBE3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 109 kDa
• Gene Name: signal peptide, CUB domain and EGF like domain containing 3
• Database Link:
  NP_689966
  Entrez Gene 222663 Human
  UniProt ID Q8IX30
• Background: SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.
• Synonyms: CEGF3

Reference Data

• Protein Families: Druggable Genome, Secreted Protein