IKB alpha (NFKBIA) Rabbit Polyclonal Antibody
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Transient overexpression lysate of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA)
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Recombinant protein of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA), 20 µg
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Other products for "IKB alpha"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:200 |
Reactivities | Human, Mouse, Rat |
Modifications | Phospho-specific |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | A synthesized peptide derived from human I?B-a around the phosphorylation site of Sersine 32/Sersine 36 |
Formulation | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration | lot specific |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | NFKB inhibitor alpha |
Database Link | |
Background | The NF-?B/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory I?B proteins . Activation occurs via phosphorylation of I?Ba at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-?B. I?Ba phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate I?B at these activating sites have been identified. |
Synonyms | IKBA; MAD-3; NFKBI |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.