NOTCH4 Rabbit Polyclonal Antibody

CAT#: TA321659

Anti-NOTCH4 Rabbit Polyclonal Antibody

Product Images

Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using TA321659 (NOTCH4 Antibody) at dilution 1/20. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 25-50
  Positive control: Human esophagus cancer
  Predicted cell location: Cell membrane
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from C' 1989-2003 amino acids of Human notch 4
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: notch 4
• Database Link:
  NP_004548
  Entrez Gene 4855 Human
  UniProt ID Q99466
• Background: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats; and an intracellular domain consisting of multiple; different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia; notch interaction with its cell-bound ligands (delta; serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human; but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network; and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands; and may play a role in vascular; renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
• Synonyms: INT3

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Dorso-ventral axis formation, Notch signaling pathway