Pleiotrophin (PTN) Rabbit Polyclonal Antibody

CAT#: TA321534

Anti-PTN Rabbit Polyclonal Antibody


USD 380.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications WB
Recommended Dilution WB: 500-2000
WB positive control: Human colon cancer tissue
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to a region derived from 33-47 amino acids of human pleiotrophin
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 19 kDa
Gene Name pleiotrophin
Background Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts; epithelial; and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation; an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Synonyms HARP; HBGF8; HBNF; NEGF1
Reference Data
Protein Families Druggable Genome, Phosphatase, Secreted Protein, Transmembrane

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