Pleiotrophin (PTN) Rabbit Polyclonal Antibody
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Other products for "Pleiotrophin"
Specifications
Product Data | |
Applications | WB |
Recommended Dilution | WB: 500-2000 WB positive control: Human colon cancer tissue |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to a region derived from 33-47 amino acids of human pleiotrophin |
Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 19 kDa |
Gene Name | pleiotrophin |
Database Link | |
Background | Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts; epithelial; and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation; an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. |
Synonyms | HARP; HBGF8; HBNF; NEGF1 |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase, Secreted Protein, Transmembrane |
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