NALP5 (NLRP5) Rabbit Polyclonal Antibody

CAT#: TA320093

Rabbit Polyclonal NALP5 Antibody

Product Images

Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of NALP5 in human brain tissue with NALP5 antibody at 10 ug/mL.

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  Immunofluorescence of NALP5 in human brain tissue with NALP5 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NALP5 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human NALP5.
• Formulation: NALP5 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: NALP5 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NLR family, pyrin domain containing 5
• Database Link:
  NP_703148
  Entrez Gene 23968 MouseEntrez Gene 308325 RatEntrez Gene 126206 Human
  UniProt ID P59047
• Background: NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.
• Synonyms: CLR19.8; MATER; NALP5; PAN11; PYPAF8