ESRP2 Rabbit Polyclonal Antibody

CAT#: TA320024

Rabbit Polyclonal RBM35B Antibody

Product Images

Western blot analysis of RBM35B in human lung tissue lysate with RBM35B antibody at 1 ug/mL.

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  Immunohistochemistry of RBM35B in human lung tissue with RBM35B antibody at 5 ug/mL.

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  Immunofluorescence of RBM35B in human lung tissue cells with RBM35B antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RBM35B antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human RBM35B.
• Formulation: RBM35B Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: RBM35B Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: epithelial splicing regulatory protein 2
• Database Link:
  NP_079215
  Entrez Gene 77411 MouseEntrez Gene 80004 Human
  UniProt ID Q9H6T0
• Background: RBM35B Antibody: RBM35A, also known as ESRP2, is a mRNA splicing factor that with its related protein RBM35A (ESRP1) are coordinators of an epithelial cell-type-specific splicing program. Both RBM35B and RBM35A are involved in posttranscriptional regulation of a number of genes such as FGFR2, CD44, CTNND1, and ENAH by exerting a differential effect on protein translation via 5' UTRs of mRNAs, suggesting that these proteins are global regulators of an epithelial regulatory network. Loss of this global ESRP-regulated epithelial splicing programme induces the phenotypic changes in cell morphology that are observed during the epithelial-mesenchymal transition.
• Synonyms: RBM35B