SLC39A1 Rabbit Polyclonal Antibody

CAT#: TA319894

Rabbit Polyclonal ZIP1 Antibody

Product Images

Western blot analysis of ZIP1 in mouse kidney tissue lysate with ZIP1 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of ZIP1 in human kidney tissue with ZIP1 antibody at 2.5 ug/mL.

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  Immunofluorescence of ZIP1 in human kidney tissue with ZIP1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZIP1 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human ZIP1.
• Formulation: ZIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ZIP1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: solute carrier family 39 member 1
• Database Link:
  NP_055252
  Entrez Gene 30791 MouseEntrez Gene 27173 Human
  UniProt ID Q9NY26
• Background: ZIP1 Antibody: ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-κB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
• Synonyms: ZIP1; ZIRTL

Reference Data

• Protein Families: Transmembrane