Snf1lk2 (SIK2) Rabbit Polyclonal Antibody
Frequently bought together (3)
Recombinant protein of human salt-inducible kinase 2 (SIK2), 20 µg
USD 867.00
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Specifications
Product Data | |
Applications | IF, WB |
Recommended Dilution | WB: 1 ug/mL |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | SIK2 antibody was raised against a 16 amino acid synthetic peptide near the center of human SIK2. |
Formulation | SIK2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | SIK2 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | salt inducible kinase 2 |
Database Link | |
Background | SIK2 Antibody: Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1 alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation. |
Synonyms | LOH11CR1I; QIK; SIK-2; SNF1LK2 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Documents
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