LASS6 (CERS6) Rabbit Polyclonal Antibody

CAT#: TA306689

Rabbit Polyclonal LASS6 Antibody

Product Images

Western blot analysis of LASS6 in rat brain tissue lysate with LASS6 antibody at (A) 1 and (B) 2 ug/ml.

• 

  Immunohistochemistry of LASS6 in mouse brain tissue with LASS6 antibody at 2.5 ug/ml.

• 

  Immunofluorescence of LASS6 in Mouse Brain cells with LASS6 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LASS6 antibody was raised against a 13 amino acid peptide near the amino terminus of the human LASS6.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ceramide synthase 6
• Database Link:
  AAI09285
  Entrez Gene 253782 Human
  UniProt ID Q6ZMG9
• Background: The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. Like the highly homologous LASS5, LASS6 is also an endoplasmic reticulum, multi-pass membrane protein. LASS6 is also involved in the synthesis of C14, C16 and C18-ceramide, but shows a preference for unsaturated fatty acids. LASS6 is broadly expressed in a wide range of tissues and microarray data suggests that it may play a role in cancer differentiation and early embryonic development. At least two isoforms of LASS6 are known to exist. This antibody is predicted not to cross-react with LASS5.
• Synonyms: CERS5; LASS6