IL17 (IL17A) Rabbit Polyclonal Antibody
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Frequently bought together (3)
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Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommended Dilution | WB: 0.125-2 µg/mL; IF: 5-20 µg/mL; IHC: 1-5 µg/mL . Antibody validated: Western Blot in human samples; Immunofluorescence in mouse samples; Immunohistochemistry in human and mouse samples. All other applications and species not yet tested. |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | IL-17 antibody was raised against a 19 amino acid synthetic peptide from near the center of human IL-17A. The immunogen is located within amino acids 50 - 100 of IL-17. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | IL-17 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | interleukin 17A |
Database Link | |
Background | Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-kB and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases. |
Synonyms | CTLA8; IL-17; IL-17A; IL17 |
Reference Data | |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction |
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