CLIP170 (CLIP1) Rabbit Polyclonal Antibody

CAT#: TA306599

Rabbit Polyclonal CLIP170 Antibody


USD 570.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 0.5 - 1 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CLIP170 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human CLIP170.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name CAP-Gly domain containing linker protein 1
Background CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin’s disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.
Synonyms CLIP; CLIP-170; CLIP170; CYLN1; RSN
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.