PHAP1 (ANP32A) Rabbit Polyclonal Antibody

CAT#: TA306129

Rabbit Polyclonal PHAP Antibody

Product Images

Western blot analysis of PHAP expression in human Raji cell lysate with PHAP antibody at 1 ug/mL. The wide and strong band below PHAP III is a doublelet composed of PHAP I (upper) and PHAP I2a (lower).

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  Immunocytochemistry of PHAP in Raji cells with PHAP antibody at 1 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PHAP antibody was raised with a synthetic peptide corresponding to amino acids at amino terminus of human PHAP.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: acidic nuclear phosphoprotein 32 family member A
• Database Link:
  NP_006296
  Entrez Gene 11737 MouseEntrez Gene 25379 RatEntrez Gene 8125 Human
  UniProt ID P39687
• Background: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis (1). PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
• Synonyms: C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency