Bim (BCL2L11) (N-term) Rabbit Polyclonal Antibody
Other products for "BCL2L11"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Western blot: 1/1000. Detects a band of approximately 22kDa in K562 and A549 whole cell lysates. Immunohistochemistry on Paraffin Sections: Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Synthetic peptide corresponding to amino acids 22 to 40 of Human Bim |
Specificity | This antibody is specific for Bcl-2 interacting mediator of cell death (Bim), also known as Bod. |
Formulation | State: Aff - Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide |
Concentration | lot specific |
Purification | Affinity Chromatography |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | BCL2 like 11 |
Database Link | |
Background | Bim is a pro-apoptotic protein within the Bcl-2 family, which functions within the intrinsic apotosis pathway. Bim is known to interact with pro-survival proteins including Bcl-2, Bcl-XL and Bcl-w. Bim is expressed in a variety of cell types, where it is maintained in an inactive conformation by phosphorylation or through binding to the microtubule-associated dynein motor complex. Upon certain apoptotic stimuli, Bim is released from microtubules and mediates caspase-dependent apoptosis. |
Synonyms | Bcl2-L-11, BCL2L11, BIM, BimEL, BimL, BimS |
Reference Data |
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