CD46 Mouse Monoclonal Antibody [Clone ID: MEM-258]
Other products for "CD46"
Specifications
Product Data | |
Clone Name | MEM-258 |
Applications | FC, IP, WB |
Recommended Dilution | Flow cytometry: 1 µg/ml. Immunoprecipitation. Western blot (Non-reducing conditions). |
Reactivities | Bovine, Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | HPB-ALL human T cell line |
Specificity | This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes. |
Formulation | Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized State: Azide Free State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Gene Name | CD46 molecule |
Database Link | |
Background | CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa. |
Synonyms | TLX, MIC10 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Complement and coagulation cascades |
Documents
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