CD59 Mouse Monoclonal Antibody [Clone ID: MEM-43]

CAT#: SM1145R

CD59 mouse monoclonal antibody, clone MEM-43, PE

Product Images

Staining of human peripheral blood lymphocytes with Mouse Anti Human CD59-RPE (SM1145R/RT).

Specifications

Product Data

• Clone Name: MEM-43
• Applications: FC
• Recommended Dilution: Flow Cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Specificity: This antibody reacts with a PI-linked glycoprotein, Mw 18-20kD found on all types of leucocytes including platelets. MEM-43 has been shown to stimulate NK activity.
• Formulation: BS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
  Label: PE
  State: Lyophilized purified IgG fraction.
  Label: R. Phycoerythrin (RPE)
• Reconstitution Method: Restore with distilled water.
• Purification: Affinity chromatography on Protein A.
• Conjugation: PE
• Storage: Prior to and following reconstitution store the antibody undiluted at 2-8°C.
  DO NOT FREEZE!
  This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: CD59 molecule
• Database Link:
  Entrez Gene 966 Human
  UniProt ID P13987
• Background: CD59 is an LY6 like protein expressed in human lymphoid cells (haemapoietic and non- haemapoietic cells), regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase
• Synonyms: MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20