Osteoprotegerin (TNFRSF11B) Mouse Monoclonal Antibody [Clone ID: OPG-01]

CAT#: DM2018

Osteoprotegerin (TNFRSF11B) mouse monoclonal antibody, clone OPG-01, Aff - Purified

Specifications

Product Data

• Clone Name: OPG-01
• Applications: ELISA, WB
• Recommended Dilution: ELISA.
  Western Blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant human Osteoprotegerin (OPG Fc Chimera) produced in E. coli.
• Specificity: The antibody recognizes human Osteoprotegerin. Other species not tested.
• Formulation: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2
  State: Aff - Purified
  State: Sterile filtered, lyophilized from 1 mg/ml solution
• Reconstitution Method: Restore with 0.1 ml of deionized water.
  Let the pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
• Concentration: lot specific
• Purification: Affinity chromatography on protein G
• Conjugation: Unconjugated
• Storage: Store lyophilized antibody at -20°C.
  Following reconstitution the antibody can be stored at 2-8°C for up to two weeks.
  For longer storage aliquot and store frozen at -20°C to -80°C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: tumor necrosis factor receptor superfamily member 11b
• Database Link:
  Entrez Gene 4982 Human
  UniProt ID O00300
• Background: Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.
• Synonyms: OPG, OCIF