Peptidase 1 / DERP1 Human Monoclonal Antibody [Clone ID: H.AK5.C]
Specifications
Product Data | |
Clone Name | H.AK5.C |
Applications | ELISA, WB |
Recommended Dilution | ELISA, Western Blot, Biopanning. Usage recommendation: *This monoclonal antibody may be used between 1-20 μg/ml. *Optimal dilution should be determined by each laboratory for each application. *Coupled antibody: to maintain RT before use. |
Reactivities | Human |
Host | Human |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | EBV cell clones derived from PBMC of allergic patients to DPT. |
Specificity | allergen of the house-dust mites Dermatophagoides pteronyssinus Derp 1 |
Formulation | 100 μg in 200 μl / 50 μg in 100 μl Tris-NaCl pH 8 State: Purified |
Concentration | lot specific |
Purification | QMA Hyper D ion exchange chromatography |
Conjugation | Unconjugated |
Storage | -20°C. KEEP CONTENTS STERILE: no preservative. Purified antibodies: avoid repeated freeze/thaw cycles. Coupled antibodies: glycerol protects from freezing. |
Background | House-dust mite allergy belongs to the most common allergies worldwide which affect more than 50% of all allergic patients. House dust mite allergens play an important role in inducing IgE-mediated sensitization and the development of bronchial hyperresponsiveness and asthma, perennial rhinitis, and atopic dermatitis. Allergic patients’s sera (IgE) recognize the house-dust mite Dermatophagoides Pteronyssinus Derp 1. The key event in these reactions is the cross-linking of IgE antibodies on effector cells by allergens, which induces a release of biologically active mediators like histamine and leukotrienes leading to different symptoms of allergy. Studies in vivo have shown that the cysteine peptidase activity of group 1 house dust mite allergens contributes to their allergenicity. (Chapman MD, 1980; J. Immunol., 125: 587-592; Hales BJ, Thomas WR., 1997; Clin. Exp. Allergy, 27(8):868- 875; Doull IJ. et al, 1997; Allergy, 52,220; Custovic A, 1996; J. Allergy Clin. Immunol., 98: 64- 72; Szalai K. et al., 2008; Mol. Immunol. 45:5, 1308-17) |
Synonyms | Allergen Der p I |
Reference Data |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.