beta Arrestin 1 (ARRB1) Mouse Monoclonal Antibody [Clone ID: OTI3F10]
CAT#: CF812547
Carrier-free (BSA/glycerol-free) ARRB1 mouse monoclonal antibody, clone OTI3F10
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI3F10 |
Applications | WB |
Recommended Dilution | WB 1:500 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human ARRB1 (NP_004032) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 47.1 kDa |
Gene Name | arrestin beta 1 |
Database Link | |
Background | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]. |
Synonyms | ARB1; ARR1 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Chemokine signaling pathway, Endocytosis, MAPK signaling pathway |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA812547 | ARRB1 mouse monoclonal antibody, clone OTI3F10 |
USD 447.00 |
|
TA812547AM | ARRB1 mouse monoclonal antibody, clone OTI3F10, Biotinylated |
USD 509.00 |
|
TA812547BM | ARRB1 mouse monoclonal antibody, clone OTI3F10, HRP conjugated |
USD 509.00 |
|
TA812547S | ARRB1 mouse monoclonal antibody, clone OTI3F10 |
USD 200.00 |
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