Factor I (CFI) Mouse Monoclonal Antibody [Clone ID: OTI4A8]
CAT#: CF806031
Carrier-free (BSA/glycerol-free) CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8)
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI4A8 |
Applications | IHC, WB |
Recommended Dilution | WB 1:2000 |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 340-583 of human CFI(NP_000195) produced in E.coli. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 63.4 kDa |
Gene Name | complement factor I |
Database Link | |
Background | This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq, Jul 2008] |
Synonyms | AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF |
Reference Data | |
Protein Families | Druggable Genome, Protease, Secreted Protein |
Protein Pathways | Complement and coagulation cascades |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA806031 | CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8) |
USD 447.00 |
|
TA806031AM | CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8), Biotinylated |
USD 509.00 |
|
TA806031BM | CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8), HRP conjugated |
USD 509.00 |
|
TA806031S | CFI mouse monoclonal antibody, clone OTI4A8 (formerly 4A8) |
USD 200.00 |
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