ERG Mouse Monoclonal Antibody [Clone ID: OTI3E12]
CAT#: CF506103
Carrier-free (BSA/glycerol-free) ERG mouse monoclonal antibody,clone OTI3E12
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI3E12 |
Applications | IF, IHC, WB |
Recommended Dilution | WB 1:200~4000, IHC 1:150, IF 1:100 |
Reactivities | Human, Dog, Mouse, Rat |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human ERG(NP_891548) produced in HEK293T cell. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 53.7 kDa |
Gene Name | ETS transcription factor ERG |
Database Link | |
Background | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan |
Synonyms | erg-3; p55 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA506103 | ERG mouse monoclonal antibody,clone OTI3E12 |
USD 224.00 |
|
TA506103AM | ERG mouse monoclonal antibody,clone 3E12, Biotinylated |
USD 509.00 |
|
TA506103BM | ERG mouse monoclonal antibody,clone 3E12, HRP conjugated |
USD 509.00 |
|
TA506103S | ERG mouse monoclonal antibody,clone OTI3E12 |
USD 200.00 |
|
TA700177 | ERG biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays |
USD 494.00 |
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