LAT2 (SLC7A8) Mouse Monoclonal Antibody [Clone ID: OTI8B12]
CAT#: CF500513
Carrier-free (BSA/glycerol-free) SLC7A8 mouse monoclonal antibody, clone OTI8B12 (formerly 8B12)
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI8B12 |
Applications | IHC, WB |
Recommended Dilution | WB 1:500 IHC 1:50 Flow 1:500 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Full-length protein expressed in 293T cell transfected with human SLC7A8 expression vector |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 58.4 kDa |
Gene Name | solute carrier family 7 member 8 |
Database Link | |
Background | Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney |
Synonyms | LAT2; LPI-PC1 |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA500513 | Anti-SLC7A8 (LAT2) mouse monoclonal antibody, clone OTI8B12 (formerly 8B12) |
USD 447.00 |
|
TA500513AM | SLC7A8 mouse monoclonal antibody, Clone 8B12, Biotinylated |
USD 509.00 |
|
TA500513BM | SLC7A8 mouse monoclonal antibody, Clone 8B12, HRP conjugated |
USD 509.00 |
|
TA500513S | Anti-SLC7A8 (LAT2) mouse monoclonal antibody, clone OTI8B12 (formerly 8B12) |
USD 200.00 |
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