MDM2 pSer186/Ser188 Rabbit Polyclonal Antibody
Other products for "MDM2"
Specifications
Product Data | |
Applications | IF |
Recommended Dilution | Immunofluorescence: 1:100~1:200. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Peptide sequence around phosphorylation site of Ser186/Ser188(H-K-S(p)-D-S(p)-I-S) derived from Human MDM2 (KLH-conjugated) |
Specificity | The antibody detects endogenous levels of MDM2 only when phosphorylated at serine 186 and serine 188. |
Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Affinity chromatography using epitope-specific peptide |
Conjugation | Unconjugated |
Storage | Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Predicted Protein Size | 55 kDa |
Gene Name | MDM2 proto-oncogene |
Database Link | |
Background | This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues |
Synonyms | p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2 |
Reference Data |
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