RNF103-CHMP3 Rabbit Polyclonal Antibody
Specifications
Product Data | |
Applications | ELISA, IF, IHC, WB |
Recommended Dilution | ELISA. Western Blot. Immunohistochemistry. |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide derived from internal domain of Human Vps24 protein |
Specificity | Reacts with 25 kDa hVps24. |
Formulation | 0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None |
Reconstitution Method | Restore in distilled water. |
Concentration | lot specific |
Purification | Affinity Chromatography on Protein A |
Conjugation | Unconjugated |
Storage | Prior to reconstitution store the antibody at -20°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | RNF103-CHMP3 readthrough |
Database Link | |
Background | The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP3, also known as Vps24, associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of CHMP3 strongly inhibits HIV-1 release. |
Synonyms | CHMP3, NEDF, CGI-149 |
Reference Data |
Documents
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