DUSP2 (C-term) Rabbit Polyclonal Antibody

CAT#: AP51339PU-N

DUSP2 (C-term) rabbit polyclonal antibody, Purified

Product Images

Western blot analysis of DUSP2 / PAC1 Antibody (C-term) in mouse liver tissue lysates (35ug/lane). DUSP2 (arrow) was detected using the purified Pab.

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  Flow cytometric analysis of HepG2 cells using DUSP2 / PAC1 Antibody (C-term) (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.

• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 269~298 amino acids from the C-terminal region of Human DUSP2
• Specificity: This antibody recognizes Human and Mouse DUSP2 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: dual specificity phosphatase 2
• Database Link:
  Entrez Gene 1844 Human
  UniProt ID Q05923
• Background:
  DUSP2 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
• Synonyms: PAC-1
• Note: Molecular Weight: 34400 Da

Reference Data

• Protein Families: Druggable Genome, Phosphatase
• Protein Pathways: MAPK signaling pathway